Volume 2, Issue 1 (Winter 2016)                   Infect Epidemiol Med 2016, 2(1): 15-17 | Back to browse issues page

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The prevalence of icaADBC Genes among Clindamycin Inducible Resistant Staphylococcus aureus Isolates. Infect Epidemiol Med. 2016; 2 (1) :15-17
URL: http://journalsystem.ir/article-1-45-en.html
Abstract:   (1017 Views)
Background: Clindamycin inducible resistant Staphylococcus aureus (S.aureus) isolates can cause failure in treatment with this antibiotic. Biofilm production via polysaccharide intercellular adhesion (PIA) contributes in the colonization of S. aureus, resulting in the initiation of different diseases. The aim of this study was to detect icaADBC genes among isolates of S.aureus with inducible resistance to clindamycin. Materials and Methods: A total of 209 clinical S.aureus isolates werecollected and identified by conventional phenotypic tests. Isolates with inducible resistance to clindamycin were detected by double disk diffusion test (D-Test) using clindamycin (2 μg) and erythromycin (15 μg). Oxacillin was used to detect Methicillin resistant Staphylococcus aureus (MRSA) isolates. Polymerase Chain Reaction (PCR) was performed to detect the icaADBC genes. Results: The rate of clindamycin inducible resistance was 4% (n=8). All the isolates were susceptible to methicillin. Four isolates (50%) contained the whole icaADBC genes. The prevalence of icaA, icaB, icaC and icaD genes were 5 (62.5%), 4 (50%), 6 (75%) and 5 (62.5%), respectively. Conclusion: The results indicate that the prevalence of  icaADBC genes among clindamycin inducible resistant strains was low, and also these strains were susceptible to methicillin.
Type of Study: Research |
Received: 2016/06/12 | Accepted: 2016/06/12 | Published: 2016/06/12

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